Forecasters expect a "major" winter storm to blanket York and Chester counties with a mix of heavy snow, sleet and freezing rain Monday and Tuesday.
The National Weather Service have upgraded the winter storm watch to a warning for the area from Sunday night through Tuesday morning.
Temperatures are expected to plunge below freezing and range from the low 20s to mid 30s throughout the storm.
While several inches of snow could fall, icy roads could make driving treacherous.
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Rock Hill has been working with the state Department of Transportation and is prepared, said city utilities director Jimmy Bagley.
"We've got utility trucks all fueled up and prepared brine solution and sand (to spread on roads to prevent icing)," he said. "We all know where we're supposed to be and what we need to do."
As is typical in these situations, Weather Service and private meteorologists caution that numerous changes in the forecast are possible before the precipitation starts around daybreak Monday. But they are convinced that some type of winter storm will cross the region.
S.C. emergency officials are also preparing for the storm.
Snow could fall in York County early Monday and continue through the day, accumulating three to five inches.
By Monday afternoon, the snow might mix with sleet, but should taper off toward evening, said Rodney Hinson, a meteorologist with the National Weather Service.
The Highway Patrol warns drivers to be wary of snow and black ice on roads, which looks like water. Slow down and keep a safe distance between vehicles, the patrol advises. Bridges and overpasses might ice before roads do.
The Highway Patrol requests that motorists dial *HP only for emergencies such as collisions or being stranded in a vehicle. Call the S.C. Department of Transportation at 511 for traffic conditions, and pay attention to advisories from local media and state agencies' websites.